Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity

Background and aim: The challenges with current antimicrobial drug therapy and resistance remain a significant global health threat. Nanodrug delivery systems are playing a crucial role in overcoming these challenges and open new avenues for effective antimicrobial therapy. While fluticasone (FLU),...

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Bibliographic Details
Main Authors:	Ahmed, S. (Author), Ali, W. (Author), Alsaid, M.S (Author), Govender, T. (Author), Hussain, Z. (Author), Khan, I. (Author), Khan, S. (Author), Shah, S.M.H (Author), Ullah, R. (Author), ur Rehman, N. (Author)
Format:	Article
Language:	English
Published:	Dove Medical Press Ltd. 2018
Subjects:	antibacterial activity Anti-Bacterial Agents antiinfective agent Antimicrobial antimicrobial activity Article chemical interaction chemical structure chemistry comparative study controlled study crystallization Crystallization differential scanning calorimetry dispersity drug binding drug carrier Drug Carriers Drug Compounding drug conformation drug delivery system Drug delivery systems drug dosage form comparison drug formulation Drug Liberation drug release drug solubility drug stability Drug Stability drug synthesis ethyl cellulose eudragit experimental study fluticasone Fluticasone Gram positive bacterium hydroxypropylmethylcellulose Hypromellose Derivatives in vitro study infrared spectroscopy methylmethacrylate-methacrylic acid copolymer molecular docking Molecular Docking Simulation molecular dynamics Molecular dynamics Molecular Dynamics Simulation molecular model Molecular modeling Molecular Structure nanofabrication nanomedicine Nanomedicine nanoparticle Nanoparticles nanopharmaceutics nonhuman particle size pharmaceutics poloxamer polymer Polymers polymethacrylic acid derivative Polymethacrylic Acids polyvinyl alcohol povidone Povidone procedures solubility Solubility storage temperature Technology, Pharmaceutical transmission electron microscopy X ray diffraction
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Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity

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