Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

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Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated sfrom the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmo...

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Bibliographic Details
Main Authors: Baba, M.S (Author), Edrada-Ebel, R. (Author), Latip, J. (Author), Mazlan, N.W (Author), Zainal-Abidin, A.H (Author), Zin, N.M (Author)
Format: Article
Language:English
Published: Dove Medical Press Ltd. 2017
Subjects:
alanine aminotransferase
alanine aminotransferase blood level
alkaline phosphatase
alkaline phosphatase blood level
animal
animal experiment
animal model
animal tissue
Animals
Antimalarial
antimalarial activity
antimalarial agent
Antimalarials
Article
aspartate aminotransferase
aspartate aminotransferase blood level
chemistry
conformation
controlled study
disease model
Disease Models, Animal
dose response
Dose-Response Relationship, Drug
drug dose comparison
drug effects
drug efficacy
drug identification
drug isolation
drug purification
drug purity
drug screening
drug sensitivity
drug structure
Endophytic
enzyme activity
gancidin w
gancidin W
Gancidin W
In vivo
in vivo study
Institute for Cancer Research mouse
isolation and purification
malaria
Malaria
male
Male
Mice
Mice, Inbred ICR
Molecular Conformation
mouse
nonhuman
Parasitic Sensitivity Tests
parasitology
piperazine derivative
Piperazines
Plasmodium berghei
Plasmodium berghei infection
protein blood level
protein determination
quinine
Shorea ovalis
Streptomyces
survival time
unclassified drug
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