The implication of the polymorphisms of COX-1, UGT1A6, and CYP2C9 among cardiovascular disease patients treated with aspirin

Purpose. Enzymes potentially responsible for the pharmacokinetic variations of aspirin include cyclooxygenase-1 (COX-1), UDP-glucuronosyltransferase (UGT1A6) and P450 (CYP) (CYP2C9). We therefore aimed to determine the types and frequencies of variants of COX-1 (A-842G), UGT1A6 (UGT1A6*2; A541G and...

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Main Authors:	Abdul Jalil, N.J (Author), Ali, O. (Author), Azreen, N.I (Author), Bannur, Z. (Author), Darinah, N. (Author), Derahman, A. (Author), Gunasekaran (Author), Hamidi, H. (Author), Kek, T.L (Author), Maskon, O. (Author), Rafizi, M. (Author), Salleh, M.Z (Author)
Format:	Article
Language:	English
Published:	Canadian Society for Pharmaceutical Sciences 2015
Subjects:	acetylsalicylic acid adolescent Adolescent adult Adult aged Aged Article Asian continental ancestry group Asian Continental Ancestry Group Aspirin bilirubin bilirubin blood level cardiovascular disease Cardiovascular Diseases Caucasian chemically induced Chinese cholesterol cholesterol blood level controlled study COX 1 gene COX-1 cyclooxygenase 1 Cyclooxygenase 1 CYP2C9 CYP2C9 gene CYP2C9 protein, human cytochrome P450 2C9 Cytochrome P-450 CYP2C9 ethnic difference European Continental Ancestry Group female Female gastritis Gastritis gene frequency gene linkage disequilibrium genetic association genetic polymorphism genetic risk genetic variability genetics glucuronosyltransferase Glucuronosyltransferase glucuronosyltransferase 1A6 high density lipoprotein high risk patient human Humans Indian international normalized ratio lipoprotein blood level low density lipoprotein major clinical study Malay (people) Malaysia male Male middle aged Middle Aged polymerase chain reaction Polymorphism, Genetic prothrombin time PTGS1 protein, human risk assessment treatment outcome Treatment Outcome UDP-glucuronosyltransferase, UGT1A6 UGT1A6 UGT1A6 gene young adult Young Adult
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The implication of the polymorphisms of COX-1, UGT1A6, and CYP2C9 among cardiovascular disease patients treated with aspirin

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