Bergenin protects pancreatic beta cells against cytokine-induced apoptosis in INS-1E cells

Bergenin protects pancreatic beta cells against cytokine-induced apoptosis in INS-1E cells

Beta cell apoptosis induced by proinflammatory cytokines is one of the hallmarks of diabetes. Small molecules which can inhibit the cytokine-induced apoptosis could lead to new drug candidates that can be used in combination with existing therapeutic interventions against diabetes. The current study...

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Bibliographic Details
Main Authors: Choudhary, M.I (Author), Mirza, M.R (Author), Rajput, S.A (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
adenosine triphosphate
Adenosine Triphosphate
animal
animal cell
Animals
antiapoptotic activity
apoptosis
Apoptosis
Article
benzopyran derivative
Benzopyrans
bergenin
biosynthesis
Casp3 protein, rat
caspase 3
Caspase 3
cell function
cell level
cell line
Cell Line
cell protection
cell survival
Cell Survival
cell viability
controlled study
cytokine
Cytokines
cytology
diabetes mellitus
drug effect
drug structure
EC50
enzyme activity
enzyme inhibition
flow cytometry
gamma interferon
glucose
Glucose
IC50
INS-1E cell line
insulin release
Insulin Secretion
Insulin-Secreting Cells
interleukin 1beta
Membrane Potential, Mitochondrial
metabolism
mitochondrial membrane potential
nitric oxide
Nitric Oxide
nitrite
nonhuman
oxidoreductase
pancreas islet beta cell
physiology
rat
Rats
reactive oxygen metabolite
Reactive Oxygen Species
tumor necrosis factor
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