Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species

Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species

Understanding relationships between spontaneous cancer in companion (pet) canines and humans can facilitate biomarker and drug development in both species. Towards this end we developed an experimental-bioinformatic protocol that analyzes canine transcriptomics data in the context of existing human...

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Bibliographic Details
Main Authors: Braisted, J. (Author), Breen, M. (Author), Gerhold, D. (Author), Grewal, G. (Author), LeBlanc, A.K (Author), Mazcko, C. (Author), Sittampalam, G. (Author), Tawa, G.J (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
animal cell
animal tissue
Animals
Article
B cell lymphoma
BACE2 gene
bioinformatics
biology
Biomarkers, Tumor
Bone Neoplasms
bone tumor
cancer model
Canis
classification
clustering algorithm
COL12A1 gene
COL5A2 gene
COL6A3 gene
Computational Biology
controlled study
CTSH gene
data classification
dog
dog disease
Dog Diseases
Dogs
EDEM1 gene
epigenetics
gene
gene activation
gene expression profiling
Gene Expression Profiling
gene expression regulation
Gene Expression Regulation, Neoplastic
gene regulatory network
Gene Regulatory Networks
genetic association
genetics
GPNMB gene
human
Humans
JAK1 gene
k nearest neighbor
LPCAT1 gene
lung carcinoma
Lung Neoplasms
lung surfactant
lung tumor
Lymphoma, B-Cell
Lymphoma, T-Cell
melanogenesis
melanoma
Melanoma
molecular fingerprinting
molecular genetics
Molecular Sequence Annotation
Molecular Targeted Therapy
molecularly targeted therapy
NAPSA gene
neoplasm
Neoplasms
nonhuman
oncogene
Oncogenes
ossification
osteosarcoma
Osteosarcoma
PMEL gene
PTK2B gene
ribosome protein
RPL8 gene
RPLP0 gene
RPS7 gene
species difference
Species Specificity
T cell lymphoma
transcriptomics
Translational Medical Research
translational research
tumor gene
tumor marker
veterinary medicine
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