GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs

GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs

Transcription factors (TFs) are proteins that promote or reduce the expression of genes by binding short genomic DNA sequences known as transcription factor binding sites (TFBS). While several tools have been developed to scan for potential occurrences of TFBS in linear DNA sequences or reference ge...

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Bibliographic Details
Main Authors: Bonnici, V. (Author), Garrison, E. (Author), Giugno, R. (Author), Pinello, L. (Author), Tognon, M. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
Article
Base Sequence
binding affinity
binding site
Binding Sites
biology
chromatin immunoprecipitation sequencing
Computational Biology
computer graphics
Computer Graphics
controlled study
DNA sequence
gene expression
genetic conservation
genetic variability
genetic variation
Genetic Variation
genetics
genome
Genome, Human
genomic DNA
genomics
Genomics
haplotype
Haplotypes
human
human genome
Humans
metabolism
nucleotide motif
Nucleotide Motifs
nucleotide sequence
position weight matrix
protein binding
Protein Binding
software
Software
transcription factor
Transcription Factors
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