Hybrid computational modeling demonstrates the utility of simulating complex cellular networks in type 1 diabetes

Hybrid computational modeling demonstrates the utility of simulating complex cellular networks in type 1 diabetes

Persistent destruction of pancreatic β-cells in type 1 diabetes (T1D) results from multifaceted pancreatic cellular interactions in various phase progressions. Owing to the inherent heterogeneity of coupled nonlinear systems, computational modeling based on T1D etiology help achieve a systematic und...

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Bibliographic Details
Main Authors: Jaberi-Douraki, M. (Author), Li, Y. (Author), Shi, Z. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
Animals
apoptosis
Article
autoantigen
Autoantigens
autoimmunity
binding site
biological model
biology
CD8+ T lymphocyte
CD8-Positive T-Lymphocytes
cell communication
Cell Communication
Computational Biology
computer model
computer simulation
Computer Simulation
cytotoxic T lymphocyte
dendritic cell
Dendritic Cells
Diabetes Mellitus, Type 1
disease exacerbation
Disease Progression
human
Humans
immunology
insulin dependent diabetes mellitus
Insulin-Secreting Cells
lymphocytic infiltration
mathematical model
Mice
Mice, Inbred NOD
Models, Immunological
mouse
nonhuman
nonobese diabetic mouse
pancreas islet beta cell
pathology
sensitivity analysis
simulation
software
Software
system analysis
Systems Analysis
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