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03607nam a2200709Ia 4500 |
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10.1364-BOE.455666 |
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220425s2022 CNT 000 0 und d |
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|a 21567085 (ISSN)
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|a Quantitative chemical sensing of drugs in scattering media with Bessel beam Raman spectroscopy
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|b Optica Publishing Group (formerly OSA)
|c 2022
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|a 15
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|z View Fulltext in Publisher
|u https://doi.org/10.1364/BOE.455666
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|a Scattering can seriously affect the highly sensitive detection and quantitative analysis of chemical substances in scattering media and becomes a significant challenge for in vivo application of Raman spectroscopy. In this study, we demonstrated a proof of concept for using the self-reconstructing Bessel beam for Raman spectroscopic sensing of the chemicals in the handmade scattering media and biological tissue slices. The homebuilt Bessel beam Raman spectroscopy (BRS) was capable of accurately detecting the Raman spectra of the chemicals buried in the scattering media, and had a superiority in quantitative analysis. The feasibility of the developed technique was verified by detecting the Raman spectra of pure samples in air. Compared with the spectra acquired by the Gaussian beam Raman spectroscope, the performance of the BRS system in terms of Raman spectrum detection and Raman peak recognition was confirmed. Subsequently, by employing the technique for the detection of acetaminophen buried in the scattering media, the application of the new technology in detecting and quantitating the chemicals in the scattering media were underlined, offering greater detection depth and better linear quantification capability than the conventional Gaussian beam Raman spectroscopy. Finally, we explored the potential of the BRS system for chemical sensing of acetaminophen in biological tissue slices, indicating a significant development towards the evaluation of drug in vivo. © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.
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|a animal experiment
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|a animal tissue
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|a Article
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|a Bessel beam
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|a Bessel beam Raman spectroscopy
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|a Biological tissues
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|a Chemical detection
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|a Chemical sensing
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|a Chemical sensors
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|a Chemical substance
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|a controlled study
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|a drug analysis
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|a drug concentration
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|a drug determination
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|a feasibility study
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|a Gaussian beam Raman spectroscopy
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|a Gaussian beams
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|a Highly sensitive detections
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|a In-vivo
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|a Laser beams
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|a light intensity
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|a light scattering
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|a mouse
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|a nonhuman
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|a paracetamol
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|a Proof of concept
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|a quantitative analysis
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|a Raman scattering
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|a Raman spectrometry
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|a Raman spectroscopy
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|a Scattering medium
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|a spectroscopy
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|a Spectrum analysis
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|a thickness
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|a Tissue
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|a tissue slice
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|a Tissue slice
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|a Vivo applications
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|a Chen, X.
|e author
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|a Li, L.
|e author
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|a Ren, F.
|e author
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|a Song, Y.
|e author
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|a Wang, H.
|e author
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|a Wang, L.
|e author
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|a Wang, N.
|e author
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|a Zeng, Q.
|e author
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|a Zeng, T.
|e author
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|a Zhu, S.
|e author
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| 773 |
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|t Biomedical Optics Express
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