The effect of Wellsolve, a novel solubilizing agent, on the intestinal barrier function and intestinal absorption of griseofulvin in rats

The effect of Wellsolve, a novel solubilizing agent, on the intestinal barrier function and intestinal absorption of griseofulvin in rats

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The effect of Wellsolve, a new solubilizing agent, on the function of intestinal membrane barrier and transporters including P-glycoprotein (P-gp) and peptide transporter (PEPT1) was examined by an in vitro diffusion chamber and an in situ closed loop method. The model drugs used in this study were...

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Bibliographic Details
Main Authors: Gao, Y. (Author), Hamid, K.A (Author), Katsumi, H. (Author), Lin, Y. (Author), Sakane, T. (Author), Yamamoto, A. (Author)
Format: Article
Language:English
Subjects:
6 carboxyfluorescein
animal experiment
Animals
Antifungal Agents
article
cefalexin
Cephalexin
Chromatography, High Pressure Liquid
concentration (parameters)
controlled study
diffusion
Diffusion
glycoprotein P
griseofulvin
Griseofulvin
in vitro study
inhibition kinetics
Intestinal absorption
Intestinal Absorption
Intestinal Mucosa
Intestinal transport
intestine absorption
intestine function
lactate dehydrogenase
lactate dehydrogenase blood level
male
Male
mucosa
nonhuman
peptide transporter 1
Pharmaceutical excipient
rat
Rats
Rats, Wistar
rhodamine 123
Rhodamine 123
serosa
Solubility
solubilizer
Solubilizing agent
unclassified drug
wellsolve
Wellsolve
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