Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments

Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments

Objectives: To explore the role of folate metabolism in 1,3-Butadiene (BD)'s genotoxicity, we conducted a match-up study in BD-exposed workers in China to analyze the associations between the polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and the chromosomal damage induced by BD e...

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Bibliographic Details
Main Authors: Ao, L. (Author), Cao, J. (Author), Ling, X. (Author), Wang, Z. (Author), Xiang, M. (Author), Zhang, G. (Author), Zhou, Z. (Author), Zou, P. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
1,3 butadiene
1,3-butadiene
5 methyltetrahydrofolic acid
5,10 methylenetetrahydrofolate reductase (FADH2)
adult
Article
butadiene diepoxide
cell culture
cell nucleus
China
Chromosomal damage
chromosome damage
clinical article
controlled study
DNA methylation
DNA methylation age
female
folate metabolism
Folate metabolism
gene frequency
genetic damage
genomic DNA
genotoxicity
genotype
human
human cell
in vitro study
lymphoblastoid cell
male
micronucleus
MTHFR
occupational exposure
Polymorphism
single nucleotide polymorphism
worker
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