New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

Background: Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have been developed to detect point mutations and deletions. The transgene is in...

Full description

Bibliographic Details
Main Authors: Ando, T. (Author), Fujiwara, S. (Author), Hayashi, H. (Author), Honma, M. (Author), Masumura, K. (Author), Nohmi, T. (Author), Suzuki, T. (Author), Takagi, H. (Author), Ukai, A. (Author), Yokose, S. (Author), You, X. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
animal tissue
Article
benzo[a]pyrene
body weight gain
body weight loss
bone marrow
chromosome 1
controlled study
DNA extraction
ethylnitrosourea
female
gene function
genomic DNA
gpt assay
gpt delta mouse
gpt delta transgenic rat
homozygosity
in vitro study
in vivo study
liver
male
mutagenesis
mutagenicity
mutant frequency
mutation spectrum
nonhuman
nucleic acid base substitution
point mutation
polymerase chain reaction
rat
Spi− assay
transgene
whole genome sequencing
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items