Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors

Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors

Background: A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings. Recent technological developments have facilitated the identification of multiple DNA adducts in a single experiment. O...

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Bibliographic Details
Main Authors: Fukazawa, A. (Author), Inaba, K. (Author), Iwashita, Y. (Author), Kurono, N. (Author), Matsumoto, K. (Author), Matsushima, Y. (Author), Matsushita, Y. (Author), Mori, H. (Author), Ochiai, H. (Author), Ohnishi, I. (Author), Ohtsuka, S. (Author), Sugimura, H. (Author), Suzuki, S. (Author), Tanioka, F. (Author), Yamashita, T. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
1,n6 etheno 2' deoxyadenosine
adductomics
aged
antioxidant
Article
autopsy
c5 hydroxymethyl 2' deoxycytidine
c5 methyl 2' deoxycytidine
c8 oxo 2' deoxyguanosine
carcinogenesis
comparative study
controlled study
deoxyadenosine
deoxycytidine
deoxyinosine
disease association
DNA
DNA adduct
DNA adductome
DNA adductomics
DNA damage
DNA determination
DNA extraction
DNA fingerprinting
drinking behavior
electrospray mass spectrometry
environmental factor
enzymatic hydrolysis
Exposure
female
gastrectomy
Gastric cancer
genomic DNA
human
human tissue
lifestyle modification
liquid chromatography
Liquid chromatography/tandem mass spectrometry
liquid chromatography-mass spectrometry
liver cell carcinoma
lung cancer
lymph node metastasis
major clinical study
male
mass spectrometry
Mutagen
n6 hydroxymethyl 2' deoxyadenosine
n6 methyl 2' deoxyadenosine
nucleoside
retention time
ribonuclease A
smoking
Stomach
stomach cancer
stomach injury
stomach mucosa
transitional cell carcinoma
unclassified drug
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