Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

A central event in the pathogenesis of motor neuron disease (MND) is the loss of neuromuscular junctions (NMJs), yet the mechanisms that lead to this event in MND remain to be fully elucidated. Maintenance of the NMJ relies upon neural agrin (n-agrin) which, when released from the nerve terminal, ac...

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Bibliographic Details
Main Authors: Chang, J. (Author), Colditz, M.J (Author), Ding, Q. (Author), Fard, A.T (Author), Gill, M. (Author), Heggie, S. (Author), Henderson, R.D (Author), Hilliard, M.A (Author), Jeffree, R.L (Author), Kesavan, K. (Author), Lee, K.M (Author), Mar, J.C (Author), McCombe, P.A (Author), Ng, D.C.H (Author), Ngo, S.T (Author), Noakes, P.G (Author), Phillips, W.D (Author), Power, D. (Author), Robertson, T. (Author), Steyn, F.J (Author), Wimberger, E. (Author), Wolvetang, E.J (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Acetylcholine receptors
Agrin
ALS
Amyotrophic Lateral Sclerosis
Motor neurons
MuSK
Neuromuscular junction
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