Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response

Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response

Background: Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the potential culprit in ICI resistance, but direct clinical evidence is lacking. Methods: Publicly available scRNA-Seq...

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Bibliographic Details
Main Authors: Chen, Y.-X (Author), Luo, H.-Y (Author), Qiu, M.-Z (Author), Wang, Z.-X (Author), Wu, H.-X (Author), Xu, R.-H (Author), Yin, L. (Author), Zeng, Z.-L (Author), Zhang, Z. (Author), Zhao, Q. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Big data analysis
Immune checkpoint therapy
Pan-cancer
Single-cell sequencing
Stemness
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