Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia 06 Biological Sciences 0604 Genetics

Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia 06 Biological Sciences 0604 Genetics

Background: The merozoite surface protein-1 (MSP-1) gene encodes for a leading malaria vaccine candidate antigen. However, its extensive polymorphic nature represents a major obstacle to the development of a protective vaccine. Previously, a pilot study was carried out to explore the sequence variat...

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Bibliographic Details
Main Authors: Choy, S.H (Author), Goh, X.T (Author), Hoh, B.P (Author), Lim, Y.A.-L (Author), Muslim, A. (Author), Ngui, R. (Author), Rajoo, Y. (Author), Vythilingam, I. (Author), William, T. (Author), Yap, N.J (Author), Yeo, T.W (Author)
Format: Article
Language:English
Published: BioMed Central 2018
Subjects:
amino acid
amino acid sequence
Amino Acid Sequence
Article
Base Sequence
Borneo
carboxy terminal sequence
classification
DNA sequence
DNA, Protozoan
gene amplification
genetic polymorphism
Genetic polymorphism
genetic selection
genetic variability
genetics
Genetics, Population
geography
Geography
haplotype
Haplotypes
malaria
Malaria
Malaysia
Merozoite surface protein
merozoite surface protein 1
Merozoite Surface Protein 1
natural selection
Natural selection
nonhuman
nucleotide sequence
parasitology
phylogeny
Phylogeny
Plasmodium knowlesi
Polymorphism, Genetic
population genetics
protozoal DNA
protozoal protein
Protozoan Proteins
sample size
Selection, Genetic
Sequence Analysis, DNA
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