ATP and NADPH engineering of Escherichia coli to improve the production of 4-hydroxyphenylacetic acid using CRISPRi

ATP and NADPH engineering of Escherichia coli to improve the production of 4-hydroxyphenylacetic acid using CRISPRi

Background: 4-Hydroxyphenylacetic acid (4HPAA) is an important raw material for the synthesis of drugs, pesticides and biochemicals. Microbial biotechnology would be an attractive approach for 4HPAA production, and cofactors play an important role in biosynthesis. Results: We developed a novel strat...

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Bibliographic Details
Main Authors: He, X. (Author), Liao, Y.-L (Author), Liu, J.-Z (Author), Lu, Q. (Author), Shen, Y.-P (Author), Yan, Z.-B (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
4-Hydroxyphenylacetic acid
ATP engineering
Biochemistry
Bioproducts
biotechnology
carboxylic acid
Cofactor engineering
coliform bacterium
CRISPRi
Encoding (symbols)
Encoding genes
enzyme
Enzymes
Escherichia coli
Fed-batch fermentation
Genes
genetic engineering
High-level production
Microbial biotechnology
NADPH engineering
Novel strategies
Palindromic
Quorum-sensing
Signal encoding
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