Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully understood. Here, we reported that viral infection could induce syncytia formation within cells...

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Bibliographic Details
Main Authors: Gao, X. (Author), Huang, H. (Author), Ma, C. (Author), Peng, H. (Author), Ren, H. (Author), Su, Y. (Author), Zhang, B. (Author), Zhou, L. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
ACE2 protein, human
Angiotensin-Converting Enzyme 2
Cell fusion
cGAS
cGAS protein, human
coronavirus spike glycoprotein
COVID-19
DNA damage
DNA Damage
DNA damage signaling
genetics
giant cell
Giant Cells
HeLa cell line
HeLa Cells
human
Humans
membrane protein
Membrane Proteins
metabolism
Micronuclei
micronucleus test
Micronucleus Tests
nucleotidyltransferase
Nucleotidyltransferases
pathogenicity
SARS-CoV-2
SARS-COV-2
signal transduction
Signal Transduction
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
STING1 protein, human
Syncytia
virology
γH2Ax
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