High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma

High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma

Background: Long-chain acyl-CoA synthetase-4 (ACSL4) is involved in fatty acid metabolism, and aberrant ACSL4 expression could be either tumorigenic or tumor-suppressive in different tumor types. However, the function and clinical significance of ACSL4 in lung adenocarcinoma remain elusive. Results:...

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Bibliographic Details
Main Authors: Li, F. (Author), Li, S. (Author), Lv, C. (Author), Yang, Q.-K (Author), Zhang, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
A-549 cell line
A549 Cells
Adenocarcinoma of Lung
adverse event
animal
Animals
Cell Line, Tumor
coenzyme A ligase
Coenzyme A Ligases
Diet, High-Fat
down regulation
Down-Regulation
drug effect
ferroptosis
Ferroptosis
gene expression regulation
Gene Expression Regulation, Neoplastic
genetics
High-fat diet
human
Humans
lipid diet
Long-chain acyl-CoA synthetase-4
long-chain-fatty-acid-CoA ligase
lung adenocarcinoma
Lung adenocarcinoma
Lung Neoplasms
lung tumor
metabolism
Mice
mouse
Neoplasm Invasiveness
pathology
tumor cell line
tumor invasion
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