Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma

Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma

Background: Chemoresistance of pancreatic cancer is the main reason for the poor treatment effect of pancreatic cancer patients. Exploring chemotherapy resistance-related genes has been a difficult and hot topic of oncology. Numerous studies implicate the key roles of circular RNAs (circRNAs) in the...

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Bibliographic Details
Main Authors: Chen, S. (Author), Chen, Z.-W (Author), Hu, J.-F (Author), Huang, L. (Author), Huang, Y. (Author), Kang, F.-P (Author), Liao, C.-Y (Author), Lin, C.-F (Author), Tian, Y.-F (Author), Wang, Z.-W (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Carcinoma, Pancreatic Ductal
Cell Line, Tumor
cell proliferation
Cell Proliferation
Circ-MTHFD1L
Deoxycytidine
doxecitine
fluorescence in situ hybridization
gemcitabine
Gemcitabine resistance
genetics
human
Humans
In Situ Hybridization, Fluorescence
metabolism
microRNA
MicroRNAs
miR-615-3p
MIRN615 microRNA, human
pancreas carcinoma
pancreas tumor
Pancreatic cancer
Pancreatic Neoplasms
RNA, Circular
RPN6
tumor cell line
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