Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

Background: Epithelial-to-mesenchymal transition (EMT) encompasses a highly dynamic and complex key process which leads to metastatic progression. In high-grade serous ovarian carcinoma (HG-SOC), endothelin-1 (ET-1)/endothelin A receptor (ETAR) signaling promotes EMT driving tumor progression. Howev...

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Bibliographic Details
Main Authors: Bagnato, A. (Author), Di Castro, V. (Author), Roman, C. (Author), Sestito, R. (Author), Tocci, P. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
AP-1
Endothelin A receptor
Epithelial-to-mesenchymal transition
ILK
Metastasis
Ovarian carcinoma
YAP
ZEB1
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