HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

Show other versions (1)

Background: Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment, tumor-associated macrophages (TAMs) provide potent pro-tumoral support. However, TAMs...

Full description

Bibliographic Details
Main Authors: Beers, S.A (Author), Booth, S.G (Author), Carter, M.J (Author), Chee, S.J (Author), Cleary, K.L.S (Author), Cragg, M.S (Author), Cutress, R.I (Author), Dahal, L.N (Author), Douglas, J. (Author), Foxall, R.B (Author), French, R.R (Author), Frendéus, B. (Author), Ghorbani, M. (Author), Glennie, M.J (Author), Hargreaves, C.E (Author), Hussain, K. (Author), James, S. (Author), Kemp, R.S (Author), Liu, R. (Author), Longley, J. (Author), Macari, S. (Author), Markham, H. (Author), Müller, K.T.J (Author), Murray, T. (Author), Oldham, R.J (Author), Ottensmeier, C.H (Author), Roghanian, A. (Author), Smith, R.C.G (Author), Stopforth, R.J (Author), Strefford, J.C (Author), Thirdborough, S.M (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
adoptive transfer
animal cell
animal experiment
animal tissue
Article
Cancer
cancer cell
cancer immunotherapy
CD20 antibody
cell hypoxia
cetuximab
chromatin immunoprecipitation
chronic lymphatic leukemia
controlled study
drug resistance
drug targeting
EL4 cell line
Fc gamma receptors
Fc receptor IIb
FcγRIIb
female
gene silencing
human
human cell
human tissue
Hypoxia
hypoxia inducible factor
Hypoxia inducible factors
in vitro study
in vivo study
leukemia cell
macrophage
male
monoclonal antibody
Monoclonal antibody
monocyte
Monocytes
mononuclear phagocyte
mouse model
multiomics
nonhuman
obinutuzumab
opsonization
peripheral blood mononuclear cell
phagocytosis
phenotype
protein expression
receptor blocking
receptor upregulation
Resistance
rituximab
small interfering RNA
spleen cell
transcription factor AP 1
transcription regulation
transgenic mouse
trastuzumab
tumor microenvironment
Tumor microenvironment
Tumor-associated macrophages
Western blotting
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items