Using affected embryos to establish linkage phase in preimplantation genetic testing for thalassemia

Using affected embryos to establish linkage phase in preimplantation genetic testing for thalassemia

Background: This study aimed to evaluate the ability of next-generation sequencing (NGS) to conduct preimplantation genetic testing (PGT) for thalassemia using affected embryos. Methods: This study included data from 36 couples who underwent PGT for thalassemia without probands and relative pedigree...

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Bibliographic Details
Main Authors: Chen, Z. (Author), Deng, Y. (Author), Liang, Y. (Author), Ou, Z. (Author), Sun, L. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Affected embryo
Monogenic diseases
Next-generation sequencing
Preimplantation genetic testing
SNP linkage
α-Thalassemia
β-Thalassemia
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