Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: Involvement of the antioxidant mechanisms

Background: Methanol extract of Bauhinia purpurea L. (family Fabaceae) (MEBP) possesses high antioxidant and anti-inflammatory activities and recently reported to exert hepatoprotection against paracetamol (PCM)-induced liver injury in rats. In an attempt to identify the hepatoprotective bioactive c...

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Bibliographic Details
Main Authors:	Hamid, S.S.A (Author), Mahmood, N.D (Author), Mamat, S.S (Author), Mohtarrudin, N. (Author), Salleh, M.Z (Author), Taher, M. (Author), Teh, L.K (Author), Yahya, F. (Author), Zakaria, Z.A (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2016
Subjects:	Acetaminophen acetic acid ethyl ester animal animal experiment animal tissue Animals antagonists and inhibitors antiinflammatory activity antioxidant Antioxidant antioxidant activity Antioxidants Article assay Bauhinia Bauhinia purpurea Bauhinia purpurea extract body weight Chemical and Drug Induced Liver Injury chemistry controlled study DPPH radical scavenging assay drug effects Fabaceae Flavonoids Hepatoprotection high performance liquid chromatography histopathology in vitro study in vivo study lipoxygenase liver Liver liver protection liver toxicity liver weight male Male methanol Methanol nonhuman ORAC assay paracetamol petroleum ether phytochemistry plant extract Plant Extracts plant leaf Plant Leaves rat Rats Rats, Sprague-Dawley silymarin Sprague Dawley rat superoxide radical scavenging assay Synergistic action xanthine oxidase
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Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: Involvement of the antioxidant mechanisms

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