Mathematical modelling of SigE regulatory network reveals new insights into bistability of mycobacterial stress response

Mathematical modelling of SigE regulatory network reveals new insights into bistability of mycobacterial stress response

Background: The ability to rapidly adapt to adverse environmental conditions represents the key of success of many pathogens and, in particular, of Mycobacterium tuberculosis. Upon exposition to heat shock, antibiotics or other sources of stress, appropriate responses in terms of genes transcription...

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Bibliographic Details
Main Authors: Del Favero, S. (Author), Di Camillo, B. (Author), Giaretta, A. (Author), Manganelli, R. (Author), Schenato, L. (Author), Zorzan, I. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Bacterial persistence
Bacterial population
bacterial protein
Bacterial Proteins
Bistability
Bi-stability
Environmental conditions
genetics
heat shock response
Heat-Shock Response
Heatshocks
Mathematical modeling
Mathematical modelling
Models, Theoretical
Mycobacterial
Mycobacterium tuberculosis
Ordinary differential equations
Regulatory network
Si-Ge alloys
sigma factor
Sigma Factor
Stresses response
theoretical model
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