KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

Background: Protein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders. Despite their clinical relevance, nearly 30% of the 545 human protein kinases remain highly understudied. Comparative genom...

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Bibliographic Details
Main Authors: Byrne, D.P (Author), Eyers, P.A (Author), Gravel, N. (Author), Huang, L.-C (Author), Kannan, N. (Author), Taujale, R. (Author), Venkat, A. (Author), Yeung, W. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Amino acids
Annotation inference
Bioinformatics
Biological Evolution
Biological functions
Comparative genomics
Enzymes
evolution
Gene ontology annotations
genetics
genomics
Genomics
Graphic methods
human
Humans
Incomplete knowledge
molecular genetics
Molecular Sequence Annotation
Neurodegenerative diseases
Neurodegenerative disorders
Neuronal development
Orthology
Potential function
protein
protein kinase
Protein kinase
Protein Kinases
protein serine threonine kinase
Proteins
Protein-Serine-Threonine Kinases
Signaling proteins
Ulk4 protein, human
Understudied proteins
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