MAPS: machine-assisted phenotype scoring enables rapid functional assessment of genetic variants by high-content microscopy

MAPS: machine-assisted phenotype scoring enables rapid functional assessment of genetic variants by high-content microscopy

Background: Genetic testing is widely used in evaluating a patient’s predisposition to hereditary diseases. In the case of cancer, when a functionally impactful mutation (i.e. genetic variant) is identified in a disease-relevant gene, the patient is at elevated risk of developing a lesion in their l...

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Bibliographic Details
Main Authors: Chao, J.T (Author), Loewen, C.J.R (Author), Roskelley, C.D (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Ability testing
Classification (of information)
Cost effectiveness
Cost-effective methods
Deep learning
Diseases
Experimental conditions
Functionalizations
High-content screening
High-throughput microscopy
human
Humans
image processing
Image Processing, Computer-Assisted
Learning services
Machine learning
microscopy
Microscopy
Optical projectors
phenotype
Phenotype
Protein subcellular localization
Single-cell phenotyping
software
Software
Software toolkits
Subcellular localizations
Tumor suppressors
Tumors
Well testing
workflow
Workflow
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