Physical and Chemical Stability of Dexamethasone Sodium Phosphate in Intravenous Admixtures Used to Prevent Chemotherapy-Induced Nausea and Vomiting

Physical and Chemical Stability of Dexamethasone Sodium Phosphate in Intravenous Admixtures Used to Prevent Chemotherapy-Induced Nausea and Vomiting

Purpose: Dilute intravenous (IV) admixtures of dexamethasone sodium phosphate (DSP) are becoming increasingly used in antiemetic regimens to prevent chemotherapy-induced nausea and vomiting (CINV). Based on its chemical structure and previous studies, DSP is known to be susceptible to hydrolysis and...

Full description

Bibliographic Details
Main Authors: Buga, I. (Author), Diep, T. (Author), McCartan, P. (Author), Rashid, K. (Author), Reindel, K. (Author), Uzoma, J.I (Author), Zhao, F. (Author)
Format: Article
Language:English
Published: SAGE Publications Ltd 2021
Subjects:
admixture programs/incompatibilities
antiemetics
Article
chemotherapy induced nausea and vomiting
compounding
concentration (parameter)
controlled study
dexamethasone sodium phosphate
drug degradation
drug packaging
drug stability
drug storage
glucose
high performance liquid chromatography
particulate matter
pH
polyvinylchloride
refrigeration
room temperature
sodium chloride
storage temperature
thermostability
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items