Antinociceptive Activity of Methanolic Extract of Clinacanthus nutans Leaves: Possible Mechanisms of Action Involved

Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways. In the present study, we aimed to further determine the possible mechanisms of antinociception of MECN using variou...

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Bibliographic Details
Main Authors:	Abdul Kadir, A. (Author), Abdul Rahim, M.H (Author), Ching, S.M (Author), Mohd Sani, M.H (Author), Omar, M.H (Author), Othman, F. (Author), Roosli, R.A.J (Author), Tohid, S.F (Author), Zakaria, Z.A (Author)
Format:	Article
Language:	English
Published:	Hindawi Limited 2018
Subjects:	Acanthaceae acetic acid acetylsalicylic acid adult agents acting on the peripheral nervous and neuromuscular systems agents interacting with transmitter, hormone or drug receptors alpha 2 adrenergic receptor analgesic agent Analgesics Analgesics, Non-Narcotic Analgesics, Opioid animal animal experiment animal model Animals antinociception antinociceptive agent apamin Article atropine beta funaltrexamine bradykinin caffeine calcium conductance capsaicin charybdotoxin chemically induced chemistry cholinergic receptor Clinacanthus nutans extract comparative study controlled study disease model Disease Models, Animal dopamine receptor dose response Dose-Response Relationship, Drug drug effect flavonoid glibenclamide glutamic acid haloperidol high performance liquid chromatography Institute for Cancer Research mouse isolation and purification licking male Male metabolism Mice Mice, Inbred ICR mouse naltrindole narcotic analgesic agent Neurotransmitter Agents nociception Nociception nonhuman norbinaltorphimine opiate receptor pain Pain phorbol 13 acetate 12 myristate physical stimulation Physical Stimulation pindolol plant extract Plant Extracts plant leaf Plant Leaves potassium channel Potassium Channel Blockers potassium channel blocking agent Potassium Channels protein kinase C retention time Sensory System Agents ultra performance liquid chromatography unclassified drug writhing test yohimbine
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Antinociceptive Activity of Methanolic Extract of Clinacanthus nutans Leaves: Possible Mechanisms of Action Involved

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