Apoptosis induction by polygonum minus is related to antioxidant capacity, alterations in expression of apoptotic-related genes, and S-phase cell cycle arrest in HepG2 cell line

Polygonum minus (Polygonaceae) is a medicinal herb distributed throughout eastern Asia. The present study investigated antiproliferative effect of P. minus and its possible mechanisms. Four extracts (petroleum ether, methanol, ethyl acetate, and water) were prepared by cold maceration. Extracts were...

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Bibliographic Details
Main Authors:	Adam, A. (Author), Al-Naqeb, G. (Author), Hazizul Hasan, M. (Author), Krishnan Selvarajan, K. (Author), Mohd Ghazali, M.A (Author)
Format:	Article
Language:	English
Published:	Hindawi Publishing Corporation 2014
Subjects:	1,1 diphenyl 2 picrylhydrazyl acetic acid ethyl ester alkaloid antioxidant antioxidant activity Antioxidants antiproliferative activity apoptosis Apoptosis article ascorbic acid Bax gene caspase 3 gene cell cycle Cell Cycle cell cycle checkpoint Cell Cycle Checkpoints chemistry chlorogenic acid confocal microscopy controlled study drug effects drug synthesis flavonoid flow cytometry gene gene expression Hep G2 Cells HepG2 cell line human human cell Humans liquid chromatography medicinal plant methanol MTT assay nucleotide sequence P53 gene petroleum ether phenol phenol derivative Phenols phytochemistry plant extract Plant Extracts plant leaf Plant Leaves Plants, Medicinal Polygonum Polygonum minus extract reverse transcription polymerase chain reaction S phase cell cycle checkpoint saponin trolox C unclassified drug upregulation vacuum liquid chromatography water
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Apoptosis induction by polygonum minus is related to antioxidant capacity, alterations in expression of apoptotic-related genes, and S-phase cell cycle arrest in HepG2 cell line

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