Activity-guided isolation of bioactive constituents with antinociceptive activity from Muntingia calabura L. Leaves using the formalin test

Activity-guided isolation of bioactive constituents with antinociceptive activity from Muntingia calabura L. Leaves using the formalin test

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The present study was conducted to determine the antinociceptive potential of methanol extract of Muntingia calabura L. (MEMC) and to isolate and identify the bioactive compound(s) responsible for the observed antinociceptive activity. The MEMC and its partitions (petroleum ether (PEP), ethyl acetat...

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Bibliographic Details
Main Authors: Ahmat, N. (Author), Lay Kek, T. (Author), Mohamad Yusof, M.I (Author), Nik Azmin, N.F (Author), Salleh, M.Z (Author), Zakaria, Z.A (Author)
Format: Article
Language:English
Subjects:
2',4' dihydroxy 3' methoxychalcone
3,7 dimethoxy 5 hydroxyflavone
5 hydroxy 3,7,8 trimethoxyflavone
acetic acid ethyl ester
acetylsalicylic acid
acute toxicity
analgesia
animal experiment
animal model
antinociception
antinociceptive agent
aqueous solution
article
calaburone
chalcone derivative
controlled study
dimethyl sulfoxide
drug identification
drug isolation
dry weight
Elaeocarpaceae
flavone derivative
formaldehyde
fractionation
male
morphine
Muntingia calabura
Muntingia calabura extract
Muntingia calabura extract fraction a
Muntingia calabura extract fraction b
Muntingia calabura extract fraction c
Muntingia calabura extract fraction d
Muntingia calabura extract fraction e
Muntingia calabura extract fraction f
Muntingia calabura extract fraction g
nonhuman
pain
partition chromatography
petroleum ether
plant extract
plant leaf
priority journal
rat
structure analysis
unclassified drug
water
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