Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes

Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes

The periodontal pathogen Tannerella forsythia has the unique ability to produce methylglyoxal (MGO), an electrophilic compound which can covalently modify amino acid side chains and generate inflammatory adducts known as advanced glycation endproducts (AGEs). In periodontitis, concentrations of MGO...

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Bibliographic Details
Main Authors: Browne, R.W (Author), Genco, R.J (Author), Honma, K. (Author), LaMonte, M. (Author), Li, M. (Author), Settem, R.P (Author), Shankar, M. (Author), Sharma, A. (Author), Xu, D. (Author)
Format: Article
Language:English
Published: Blackwell Publishing Ltd 2018
Subjects:
advanced glycation end product
advanced glycation end product receptor
AGEs
Article
bacterial enzyme
bacterial load
bacterial strain
bacterial virulence
controlled study
cytokine
cytokine release
Cytokines
deletion mutant
gel mobility shift assay
Glycation End Products, Advanced
high mobility group B1 protein
human
human cell
Humans
immunogenicity
immunoglobulin enhancer binding protein
inflammation
Inflammation
interleukin 10
interleukin 1beta
interleukin 6
MAPK signaling
metabolism
methylglyoxal
methylglyoxal synthase
microbiology
mitogen activated protein kinase p38
monocyte
Monocytes
mutant
nonhuman
osteoclastogenesis
pathogenicity
periodontitis
Periodontitis
phosphatase
protein degradation
protein function
protein glycosylation
Pyruvaldehyde
RAGE
secreted embryonic alkaline phosphatase
stress activated protein kinase
synthetase
Tannerella forsythia
THP-1 cell line
THP-1 Cells
transcription factor AP 1
tumor necrosis factor
unclassified drug
virulence factor
Virulence Factors
wild type
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