Changes in DNA methylation accompany changes in gene expression during chondrocyte hypertrophic differentiation in vitro

Changes in DNA methylation accompany changes in gene expression during chondrocyte hypertrophic differentiation in vitro

During osteoarthritis (OA), articular chondrocytes undergo phenotypic changes that resemble developmental patterns characteristic of growth plate chondrocytes. These phenotypic alterations lead to a hypertrophy-like phenotype characterized by altered production of extracellular matrix constituents a...

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Bibliographic Details
Main Authors: Lessard, S.G (Author), Mukherjee, P. (Author), Otero, M. (Author), Rourke, B. (Author), Singh, P. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
animal
animal cell
animal tissue
Animals
Article
articular cartilage
C57BL mouse
Cartilage, Articular
cell culture
cell differentiation
Cell Differentiation
Cells, Cultured
chondrocyte
chondrocytes
Chondrocytes
chondrogenesis
Chondrogenesis
controlled study
cytology
DNA methylation
DNA Methylation
Epigenesis, Genetic
epigenetics
ERRBS
gene expression
Gene Expression
genetic epigenesis
genetics
growth, development and aging
human
Humans
hypertrophy
Hypertrophy
in vitro study
Mice
Mice, Inbred C57BL
mouse
nonhuman
osteoarthritis
Osteoarthritis
pathology
physiology
reduced representation bisulfite sequencing
RNA sequencing
RNA-Seq
three dimensional cell culture
transcriptomics
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