Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells

Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells

Background: Matrix metalloproteinases (MMPs) play a crucial role in the malignant phenotype of cancer cells. In particular, active levels of MMP2 in cancer cells have been associated with invasion and metastasis through the degradation of basement membrane extracellular matrix proteins. However, lit...

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Bibliographic Details
Main Authors: Celentano, A. (Author), Cirillo, N. (Author), Koo, K. (Author), McCullough, M. (Author), Mirams, M. (Author), Paolini, R. (Author), Yap, T. (Author), Yiannis, C. (Author)
Format: Article
Language:English
Published: Blackwell Publishing Ltd 2021
Subjects:
adult
arp 101
Article
cancer grading
cancer tissue
carcinogenesis
Carcinoma, Squamous Cell
cell invasion
cell invasion assay
Cell Line, Tumor
cell migration
cell motion
Cell Movement
cell proliferation
cell survival
cell viability
controlled study
enzyme inhibition
female
gelatinase A
H357 cell line
H400 cell line
Head and Neck Neoplasms
head and neck tumor
histopathology
human
human cell
human tissue
Humans
immunohistochemistry
in vitro study
keratinocytes
major clinical study
male
matrigel
Matrix Metalloproteinase 2
matrix metalloproteinase inhibitor
matrix metalloproteinases
messenger RNA
middle aged
MMP2
monoclonal antibody
monoclonal antibody MA513590
Mouth Neoplasms
mouth squamous cell carcinoma
mouth tumor
neutralizing antibody
oral cancer
oral squamous cell carcinoma cell line
priority journal
protein expression
squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
tissue microarray
transwell assay
tumor cell line
unclassified drug
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