Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Macrophage-stimulator of interferon genes (STING) signaling mediated sterile inflammation has been implicated in various age-related diseases. However, whether and how macrophage mitochondrial DNA (mtDNA) regulates STING signaling in aged macrophages remains largely unknown. We found that hypoxia-re...

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Bibliographic Details
Main Authors: Chen, Z. (Author), Hu, H. (Author), Pan, X. (Author), Rao, Z. (Author), Sun, Y. (Author), Tang, W. (Author), Wang, P. (Author), Wang, X. (Author), Xia, Y. (Author), Xu, J. (Author), Zhong, W. (Author), Zhou, H. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
aging
animal
Animals
cytosol
Cytosol
DNA, Mitochondrial
genetics
human
Humans
inflammation
Inflammation
liver
Liver
macrophage
Macrophages
metabolism
Mice
Mitochondria
mitochondrial DNA
mitochondrion
mitophagy
Mitophagy
mouse
nucleotidyltransferase
Nucleotidyltransferases
protein kinase
Protein Kinases
signal transduction
Signal Transduction
sterile inflammation
stimulator of interferon genes
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