Recovery of Conformational Continuum from Single-particle Cryo-EM Images: Optimization of ManifoldEM Informed by Ground Truth

Recovery of Conformational Continuum from Single-particle Cryo-EM Images: Optimization of ManifoldEM Informed by Ground Truth

This work is based on the manifold-embedding approach to study biological molecules exhibiting continuous conformational changes. Previous work established a methodnow termed ManifoldEMcapable of reconstructing 3D movies and accompanying free-energy landscapes from single-particle cryo-EM images of...

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Bibliographic Details
Main Authors: Acosta-Reyes, F. (Author), Frank, J. (Author), Maji, S. (Author), Schwander, P. (Author), Seitz, E. (Author)
Format: Article
Language:English
Published: Institute of Electrical and Electronics Engineers Inc. 2022
Subjects:
Bioinformatics
Biology
biomolecules
Conformations
Degrees of freedom (mechanics)
Electric fields
Embeddings
Free energy
Free energy landscape
free-energy landscape
Image reconstruction
Images reconstruction
Imaging
kernel methods
Kernel-methods
Learning systems
Manifold
manifold embedding
Manifold embedding
Manifolds
Medical imaging
Principal component analysis
Principal-component analysis
Proteins
quantitative biology
Quantitative biology
Single particle cryogenic microscopy
single particle cryogenic microscopy (cryo-EM)
Single-particle
spectral geometry
Spectral geometry
Three dimensional displays
Three-dimensional display
Three-dimensional displays
unsupervised machine learning
Unsupervised machine learning
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