KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization

KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization

The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 mRNA and decrease neurite growth in cultured embryonic neurons. Here, we have tested functions of KHSRP in vivo. We find upregulat...

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Bibliographic Details
Main Authors: Allan, A.M (Author), Brigman, J.L (Author), Buchanan, C.N (Author), Cole, R. (Author), Dell’Orco, M. (Author), Gardiner, A.S (Author), Mudge, J. (Author), Olguin, S.L (Author), Ortinski, P. (Author), Patel, P. (Author), Perrone-Bizzozero, N.I (Author), Sundararajan, A. (Author), Twiss, J.L (Author), Vaughn, L.S (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
adult
animal cell
animal experiment
article
attention
axon
axon guidance
controlled study
dendrite
dendritic spine
embryo
excitatory postsynaptic potential
gene deletion
gene expression
genetic transcription
hippocampus
in vivo study
infralimbic cortex
knockout gene
long term memory
male
memory consolidation
mouse
neocortex
nerve cell
nerve cell culture
neurotransmission
nonhuman
protein function
synaptic transmission
transcription initiation
upregulation
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