Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study

Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study

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Here in this study regarding the over expression of TP, which causes some physical, mental and socio problems like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. By this consideration, the inhibition of this enzyme is vital to secure life from serious threa...

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Bibliographic Details
Main Authors: Ahmed, Q.U (Author), Rahim, F. (Author), Shah, S.A.A (Author), Taha, M. (Author), Wadood, A. (Author), Zakaria, Z.A (Author), Zaman, K. (Author)
Format: Article
Language:English
Published: Nature Publishing Group 2019
Subjects:
7-deazaxanthine
binding site
Binding Sites
chemistry
enzyme inhibitor
Enzyme Inhibitors
enzymology
Escherichia coli
Escherichia coli protein
Escherichia coli Proteins
human
Humans
IC50
Inhibitory Concentration 50
isoquinoline
isoquinoline derivative
Isoquinolines
Magnetic Resonance Spectroscopy
metabolism
molecular docking
Molecular Docking Simulation
nuclear magnetic resonance spectroscopy
oxadiazole derivative
Oxadiazoles
Protein Structure, Tertiary
protein tertiary structure
structure activity relation
Structure-Activity Relationship
synthesis
thymidine phosphorylase
Thymidine Phosphorylase
xanthine derivative
Xanthines
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