A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2

A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2

Respiratory tract vaccination has an advantage of needle-free delivery and induction of mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human parainfluenza virus type 3 vector to generate constructs expressing the full spike (S) protein of SARS-CoV-2, its S1 subunit, or the re...

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Bibliographic Details
Main Authors: Bharaj, P. (Author), Bukreyev, A. (Author), Chikina, M. (Author), Endsley, J.R (Author), Endsley, M.A (Author), Huang, K. (Author), Ilinykh, P.A (Author), Kuzmin, I.V (Author), Kuzmina, N.A (Author), Meyer, M.N (Author), Mire, C.E (Author), Periasamy, S. (Author), Ramanathan, P. (Author), Sealfon, S.C (Author), Widen, S.G (Author)
Format: Article
Language:English
Published: Nature Research 2022
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