Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair
DNA ligase I (LIG1) catalyzes the ligation of the nick repair intermediate after gap filling by DNA polymerase (pol) β during downstream steps of the base excision repair (BER) pathway. However, how LIG1 discriminates against the mutagenic 3′-mismatches incorporated by polβ at atomic resolution rema...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Research
2022
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| Online Access: | View Fulltext in Publisher |