Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression

Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression

Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen expression by cancer cells and their immunogenicity in mice and in patients with malignancies. A crucial role in the mitochondrial fragmentation connection with immunogenicity is played by the IRE1α-XBP-1s axis. XBP...

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Main Authors: Chen, B. (Author), Chen, W. (Author), Fan, S. (Author), Ferrone, S. (Author), Fu, S. (Author), Lei, X. (Author), Li, J. (Author), Li, Q. (Author), Lin, H. (Author), Lv, X. (Author), Ou, Z. (Author), Pan, G. (Author), Ruan, Y. (Author), Sadagopan, A. (Author), Tannous, B.A (Author), Tian, T. (Author), Wang, J. (Author), Xia, X. (Author), Xie, S. (Author), Yuan, X. (Author), Zhou, J. (Author), Zhu, X. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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