Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

An excitatory neuron subset in the spinal dorsal horn (SDH) that expresses gastrin-releasing peptide receptors (GRPR) is critical for pruriceptive transmission. Here, we show that glutamatergic excitatory inputs onto GRPR+ neurons are facilitated in mouse models of chronic itch. In these models, neu...

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Bibliographic Details
Main Authors: Asai, K. (Author), Kanehisa, K. (Author), Koga, K. (Author), Maejima, S. (Author), Sakamoto, H. (Author), Shiraishi, Y. (Author), Shiratori-Hayashi, M. (Author), Tsuda, M. (Author), Worley, P.F (Author), Xiao, M.-F (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
animal
Animals
bombesin receptor
C reactive protein
C-Reactive Protein
genetics
metabolism
Mice
mouse
nerve cell
nerve protein
Nerve Tissue Proteins
neuronal pentraxin
Neurons
posterior horn cell
Posterior Horn Cells
pruritus
Pruritus
Receptors, Bombesin
ubiquitin protein ligase
Ubiquitin-Protein Ligases
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