Kronos scRT: a uniform framework for single-cell replication timing analysis

Kronos scRT: a uniform framework for single-cell replication timing analysis

Mammalian genomes are replicated in a cell type-specific order and in coordination with transcription and chromatin organization. Currently, single-cell replication studies require individual processing of sorted cells, yielding a limited number (<100) of cells. Here, we develop Kronos scRT, a so...

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Bibliographic Details
Main Authors: Baudrin, L.G (Author), Baulande, S. (Author), Bohec, M. (Author), Chen, C.-L (Author), Dumont, M. (Author), Fachinetti, D. (Author), Gnan, S. (Author), Josephides, J.M (Author), Saulebekova, D. (Author), Spagnuolo, M. (Author), Wu, X. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
animal cell
animal experiment
article
cell cycle S phase
cell division
cell population
cell selection
controlled study
human
male
mouse
nonhuman
software
stochastic model
whole genome sequencing
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