Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content
Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the human neural tissue is poorly understood. Here, we derive neural progenitor cells, neurons, and brain organoids from skin fibroblast...
Main Authors: | Araújo, B.M.P (Author), Avansini, S.H (Author), Camargo, A.P (Author), Carvalho, V.M.A (Author), de Souza, J.S (Author), Haddad, G.G (Author), LaMontagne, E. (Author), Muotri, A.R (Author), Nakahara, T.S (Author), Papes, F. (Author), Sánchez-Sánchez, S.M (Author), Santo, C.N (Author), Szeto, R.A (Author), Teixeira, J.R (Author), Velho, P.E.N.F (Author), Wu, W. (Author), Yao, H. (Author) |
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Format: | Article |
Language: | English |
Published: |
Nature Research
2022
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Online Access: | View Fulltext in Publisher |
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