Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the human neural tissue is poorly understood. Here, we derive neural progenitor cells, neurons, and brain organoids from skin fibroblast...

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Bibliographic Details
Main Authors: Araújo, B.M.P (Author), Avansini, S.H (Author), Camargo, A.P (Author), Carvalho, V.M.A (Author), de Souza, J.S (Author), Haddad, G.G (Author), LaMontagne, E. (Author), Muotri, A.R (Author), Nakahara, T.S (Author), Papes, F. (Author), Sánchez-Sánchez, S.M (Author), Santo, C.N (Author), Szeto, R.A (Author), Teixeira, J.R (Author), Velho, P.E.N.F (Author), Wu, W. (Author), Yao, H. (Author)
Format: Article
Language:English
Published: Nature Research 2022
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