Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Preneoplastic mammary tissues from human female BRCA1 mutation carriers, or Brca1-mutant mice, display unexplained abnormalities in luminal differentiation. We now study the division characteristics of human mammary cells purified from female BRCA1 mutation carriers or non-carrier donors. We show pr...

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Bibliographic Details
Main Authors: Aalam, S.M.M (Author), Bottyan, J. (Author), Chen, K. (Author), Eaves, C.J (Author), Ghorayeb, R. (Author), He, Z. (Author), Kannan, N. (Author), Lange, P.F (Author), Lorentzian, A.C (Author), Maxwell, C.A (Author), Pujana, M.A (Author), Tan, S. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
animal
Animals
BRCA1 protein
BRCA1 Protein
BRCA1 protein, human
breast
Breast
Breast Neoplasms
breast tumor
cell division
Cell Division
cell transformation
Cell Transformation, Neoplastic
DNA damage
DNA Damage
female
Female
genetics
human
Humans
metabolism
Mice
mouse
mutation
Mutation
spindle apparatus
Spindle Apparatus
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