A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening

Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six...

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Main Authors:	Adami, H.-O (Author), Bei, J. (Author), Cai, Y. (Author), Cao, L. (Author), Cao, S. (Author), Chang, E.T (Author), Deng, B. (Author), Deng, C. (Author), Dong, S. (Author), Fan, P. (Author), Feng, L. (Author), Feng, Y. (Author), He, Y.-Q (Author), Hu, Y. (Author), Hu, Z. (Author), Huang, G. (Author), Ji, M. (Author), Jia, W.-H (Author), Jia, Y. (Author), Jin, G. (Author), Kozlakidis, Z. (Author), Lam, T.-H (Author), Li, D. (Author), Li, F. (Author), Li, X. (Author), Liang, X. (Author), Liao, Y. (Author), Liu, J. (Author), Liu, Q. (Author), Lung, M.L (Author), Luo, L. (Author), Ma, J. (Author), Mai, H. (Author), Mai, Z.-M (Author), Qin, W. (Author), Shen, H. (Author), Song, J. (Author), Sun, Y. (Author), Tang, M. (Author), Tong, X. (Author), Wang, R. (Author), Wang, T.-M (Author), Wu, B. (Author), Wu, Y. (Author), Wu, Z. (Author), Xiao, R. (Author), Xie, S.-H (Author), Xu, M. (Author), Xue, W. (Author), Yang, D. (Author), Ye, W. (Author), Yuan, L. (Author), Zeng, Y.-X (Author), Zhan, J. (Author), Zhang, J. (Author), Zhang, P. (Author), Zhang, S. (Author), Zhang, W. (Author), Zhang, Z. (Author), Zheng, M. (Author), Zheng, X. (Author), Zheng, Y. (Author), Zhou, T. (Author), Zhou, Y. (Author)
Format:	Article
Language:	English
Published:	Nature Research 2022
Subjects:	case control study Case-Control Studies clinical trial genetics genome-wide association study Genome-Wide Association Study human Humans multicenter study Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms nasopharynx carcinoma nasopharynx tumor risk assessment Risk Assessment risk factor Risk Factors
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A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening

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