Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration

Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration

Subanesthetic-dose racemic (R,S)-ketamine (ketamine) produces rapid, robust, and sustained antidepressant effects in major depressive disorder (MDD) and bipolar disorder (BD) and has also been shown to effectively treat neuropathic pain, complex regional pain syndrome, and post-traumatic stress diso...

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Bibliographic Details
Main Authors: Acevedo-Diaz, E.E (Author), Cavanaugh, G.W (Author), Farmer, C.A (Author), Ferrucci, L. (Author), Gould, T.D (Author), Kadriu, B. (Author), Lovett, J. (Author), Moaddel, R. (Author), Morris, P.J (Author), Park, L.T (Author), Thomas, C.J (Author), Yavi, M. (Author), Yuan, P. (Author), Zanos, P. (Author), Zarate, C.A., Jr (Author)
Format: Article
Language:English
Published: Springer Nature 2022
Subjects:
animal
Animals
antidepressant agent
Antidepressive Agents
brain
Brain
Depressive Disorder, Major
human
Humans
ketamine
Ketamine
major depression
metabolism
metabolomics
Metabolomics
Mice
mouse
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