Graph Convolutional Network-Based Screening Strategy for Rapid Identification of SARS-CoV-2 Cell-Entry Inhibitors

Graph Convolutional Network-Based Screening Strategy for Rapid Identification of SARS-CoV-2 Cell-Entry Inhibitors

The cell entry of SARS-CoV-2 has emerged as an attractive drug development target. We previously reported that the entry of SARS-CoV-2 depends on the cell surface heparan sulfate proteoglycan (HSPG) and the cortex actin, which can be targeted by therapeutic agents identified by conventional drug rep...

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Bibliographic Details
Main Authors: Chen, C.Z (Author), Gao, P. (Author), Guo, H. (Author), Shen, M. (Author), Xu, M. (Author), Ye, Y. (Author), Zhang, Q. (Author), Zheng, W. (Author)
Format: Article
Language:English
Published: American Chemical Society 2022
Subjects:
Cell membranes
Cell-surface heparan
Classification (of information)
Convolution
Convolutional networks
Cortexes
Cytology
Development targets
Drug development
Heparan sulfate proteoglycans
Network-based
Proteins
Rapid identification
SARS
Screening strategy
Sulfur compounds
Therapeutic agents
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