Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis
Poxviruses encode decapping enzymes that remove the protective 5′ cap from both host and viral mRNAs to commit transcripts for decay by the cellular exonuclease Xrn1. Decapping by these enzymes is critical for poxvirus pathogenicity by means of simultaneously suppressing host protein synthesis and l...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cell Press
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |