Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular states during in vitro differentiation has not been performed....

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Main Authors: André, H. (Author), Aronsson, M. (Author), Baqué-Vidal, L. (Author), Bartuma, H. (Author), Bhaduri, A. (Author), Douagi, I. (Author), Efstathopoulos, P. (Author), Jaberi, E. (Author), Khven, I. (Author), Kriegstein, A. (Author), Kvanta, A. (Author), La Manno, G. (Author), Lanner, F. (Author), Lederer, A.R (Author), Pannagel, B. (Author), Petrus-Reurer, S. (Author), Shimizu, Y. (Author), Sundstrӧm, E. (Author), Villaescusa, J.C (Author), Wagner, M. (Author), Willenbrock, H. (Author), Wrona, A. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
age-related macular degeneration
animal
Animals
cell differentiation
Cell Differentiation
cellular profiling and transcriptome
cellular therapy
clinical translation
differentiation protocol dynamics
genetics
human
human embryonic stem cell
human embryonic stem cell-derived retinal pigment epithelial cell
Human Embryonic Stem Cells
Humans
Large-eyed model
macular degeneration
Macular Degeneration
retinal pigment epithelium
Retinal Pigment Epithelium
Retinal Pigments
retinal progenitor cells
single-cell RNA sequencing
subretinal injection
visual pigment
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